It can be eliminated predominantly by hepatic metabolism (mostly CYP3A4) and is transformed to an active metabolite with Attributes much like the mother or father, sildenafil. The two sildenafil and also the metabolite have terminal 50 % lives of about four several hours.
Administration of VIAGRA with nitric oxide donors including organic and natural nitrates or natural nitrites in any type is contraindicated.
i.d.) resulted in a very 63% lessen of sildenafil AUC and a fifty five% reduce in sildenafil Cmax . Concomitant administration of robust CYP3A4 inducers, which include rifampin, is expected to induce greater decreases in plasma levels of sildenafil.
Always consult your Health care company to guarantee the information exhibited on this webpage applies to your own situation.
There are no controlled clinical data on the protection or efficacy of VIAGRA in individuals with retinitis pigmentosa (a minority of those sufferers have genetic disorders of retinal phosphodiesterases); if prescribed, This could be done with warning.
The protection of VIAGRA is unknown in people with bleeding Ailments and patients with Lively peptic ulceration.
So currently, there’s not sufficient information to understand of course if Viagra is Risk-free or productive in females. If you’d like to understand more about how Viagra influences ladies, speak with your doctor.
But For those who have an erection that lasts more time than 4 several hours, check with a health care provider at once. This might be a healthcare crisis, and it might cause damage to your penis.
Sexually transmitted bacterial infections: Sildenafil doesn't guard towards sexually transmitted bacterial infections such as HIV.
Disclaimer: Healthline has manufactured every exertion to make specified that all information and facts is factually appropriate, complete, and updated. Having said that, this informative article shouldn't be applied instead for the understanding and knowledge of a licensed Health care professional. You ought to constantly talk to your health practitioner or A different healthcare Expert ahead of getting any medication.
Sometimes, your health practitioner might keep an eye on you much more than common, or they may advise a unique medication for you.
Usually do not get sildenafil If you're also employing a nitrate drug for upper body agony or coronary heart challenges. This consists of nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
Stronger CYP3A4 inhibitors for example ketoconazole or website itraconazole might be envisioned to have better outcomes than noticed with saquinavir. A beginning dose of twenty five mg of VIAGRA need to be deemed in individuals using erythromycin or sturdy CYP3A4 inhibitors (including saquinavir, ketoconazole, itraconazole) [see DOSAGE AND ADMINISTRATION, Scientific PHARMACOLOGY].
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